Since mitochondria produce energy for the cell, and PQQ helps mitochondria work more efficiently, there is an overall increase of energy within your cells. The unused cellular energy is transferred to other parts of your body. If you struggle to have energy to make it through the day, or you experience fatigue or lethargy, this added boost of energy from PPQ will be important to you. One study found that participants who reported having problems with their energy, experienced a noticeable decrease in their fatigue after taking PQQ. If you’re looking for a boost to your energy, PQQ may help with that.

PQQ can be effective as anti-aging prevention not just for your brain, heart, and liver, but also as a cosmetic anti-aging treatment for your skin. PQQ has been shown to rejuvenate skin cells and rebuild healthy tissue for thicker skin and fewer wrinkles.  PQQ enhances the incorporation of [³H]-thymidine into human skin fibroblasts cultured in medium containing PQQ at concentrations as low as 3 nM.

PQQ supplementation is associated with improved sleep quality and duration. Mood also was improved by diminishing feelings of fatigue, and improved QOL on measures of appetite, sleep, pain and obsession. Researches indicate that PQQ can be regarded as a useful dietary supplement  relate to improving fatigue. Importantly, no health issues were associated with PQQ supplementation.

With a reduced amount of stress, researchers have begun to see improvements to memory. In this case, the combination of PQQ and CoQ10 may lead to memory enhancement and promoting cognitive health. 

Head injuries and strokes: 

• Suppresses reactive nitrogen species, which spike in strokes and brain injuries. In this way, it provides protection against neuro-related injuries.
• Suppresses inflammatory cytokines. 
• Binds up damaged cells and neurotoxins, such as glutamate, in your brain. 
• Rescues hippocampal neurons.
• Decreases the size of the damaged area in strokes and traumatic brain injuries. 

Alzheimer’s disease 

• Blocks the damage of amyloid beta—the main component of the amyloid plaques found in the brains of people with Alzheimer’s disease. PQQ acts after amyloid beta has already accumulated, helping cells recover from amyloid beta-induced oxidant stress, preventing neuronal cell death, and decreasing further production of reactive oxygen species. 
• Protects the brain against neurotoxicity induced by powerful toxins, such as mercury and oxidopamine, that are suspected to play a role in Alzheimer’s disease. 
• Protects and rescues hippocampal memory cells.

 Parkinson’s disease

• Increases a protein called DJ-1. This protein, which increases cell function and survival by combating intensive oxidative stress, is important for brain health and function. DJ-1 mutations have been linked to the onset of rare inherited forms of Parkinson’s disease and other neurological disorders. 
• Protects the brain against neurotoxicity induced by powerful toxins, such as mercury and oxidopamine, that are suspected to play a role in Parkinson’s disease. 
• Prevents the aggregation of alpha-synuclein proteins associated with Parkinson’s disease. 

Dementia

• Prevents the aggregation of alpha-synuclein proteins associated with Lewy Body Dementia.  

PQQ improves blood circulation and cardiac function, supporting energy production in the heart and providing powerful antioxidant protection. It also offers the following benefits: 

• Reduces the size of damaged areas in the heart from an acute heart attack. 
• Protects against heart muscle dysfunction and reduces cellular damage. 
• Helps heart muscle cells resist acute oxidative stress by preserving and enhancing mitochondrial function. 

PQQ aids the liver with fat metabolism, breaking down more fat and converting it into greater energy output. Studies indicate that it may also reverse acute and chronic liver injury, including damage from fatty liver disease.