Enzyme Engineering
Directed coEnzyme & Protein Evolution
JEMBIOSCIENCE is applies directed molecular evolution to improving healthcare by discovering, optimizing and developing human biotherapeutics.
Mutation, selection, reproduction, repeat for millions of generations—every biologist is familiar with how evolution has resulted in the incredible diversity and adaptations found in the natural world. Directed evolution uses a similar strategy to create biomolecules for use in diverse fields spanning industrial production, medical science, and basic research. The crucial difference is that, with directed evolution, results can be achieved much more quickly, in many cases with just a few rounds of mutagenesis and selection.
These include enzymes involved in post-translational modifications such as ubiquitination, glycosylation, or phosphorylation, enzymes with immunotherapeutic potential, and enzymes used for bioprocessing applications. Engineered enzymes have already showed growing use in therapeutic and industrial products.
- Specialized expertise and resources
- Powerful computational modeling
- Construction of large mutant libraries
- High throughput screening
- Results analysis